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Soy isoflavone-specific biotransformation product S-equol in the colon: physiological functions, transformation mechanisms, and metabolic regulatory pathways

doi: 10.1046/j.1432-1327.1999.00646.x Fletcher, Jamie I., Dingley, Andrew J., Smith, Ross, Connor, Mark, Christie, MacDonald J

When consumed as a standard powder or tablet, the fragile tripeptide structure is rapidly degraded by gastric enzymes (such as gamma-glutamyltransferase) and undergoes aggressive first-pass hepatic metabolism, reducing the amount of GSH in the blood [2]

C., Barajas, R

MG: Writing original draft

Our findings suggest that BDFs anticonstipation effects are dose-dependent, with high doses significantly improving outcomes, including fecal count, water content, and propulsion rate