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control FoB (Supplementary Fig

In this context, autophagy serves a protective role by repairing damaged organelles and proteins, thus helping to maintain kidney function and structure ( Oxidative stress and DKD are closely linked in the pathogenesis of the disease ( Since mTORC1 plays a central role in cellular metabolism, ROS can influence the overall metabolic state of cells by regulating mTORC1 activity (Yasuda-Yamahara et al., 2021)

Oxidized redox state of glutathione in the endoplasmic reticulum

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During the degradation stage, a cell retrieves amino acids and other precursor molecules from degraded proteins and removes damaged structures that may disturb its homeostasis