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COX-1 induction leads to a substantial increase in thromboxane A2 (TXA 2 ) in human endothelial cells, while induction of COX-2 by IL-1B leads to a minor increase in TXA 2 but a substantial induction of the proinflammatory proteins prostacyclin (PGI 2 ) and prostaglandin E2 (PGE 2 ) (232)

Super-enhancers delineate disease-associated regulatory nodes in T cells

Additionally, PP2A dephosphorylates carbohydrate-responsive element-binding protein (ChREBP), a transcription factor that upregulates the expression of hepatic genes involved in lipid synthesis

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A., "Alternative polyadenylation can regulate post-translational membrane localization", Trends in Cell and Molecular Biology 10: 37-47 (2015)