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To investigate the impact of HBV infection on innate immune response to bepirovirsen, WT littermate control and transgenic hTLR8 mice were infected with 1x10^11 viral genome per mouse of AAV-HBV for at least 30 days prior to study start

The ability of NRF2 to regulate xCT coupled with the decline of NRF2 with age 178 might account for the increased levels of plasma cystine seen with increasing age

The study protocols were approved by the Institutional Animal Care and Use Committee of the Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences [SYXK (Jing)2017-0023]

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-HIV-and nerve injury-associated peripheral sensory neuropathy via block of N-and T-type calcium channels

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Dustin CM, Heppner DE, Lin MJ, van der Vliet A