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They comprise an equal number of males and females aged 39 to 52 years old (average age 44.70 4.94 years)

Aging-related ovarian failure and infertility: melatonin to the rescue

Considering the emerging link between impaired cerebellar function and mania, and that decreased serum BDNF is a biomarker of bipolar disorder, the decrease in cerebellar BDNF expression in the Camkk2 and Camk4 null mice suggests that defects in CaMKK2-CaMK4 signalling within the cerebellum may be involved in triggering manic behaviour [46,47,48,49]

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Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity