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Therefore, carnitine participation in redox signaling and affecting transcription factors (Nrf2, PPAR, NF-B, etc.) as well as activating the vitagene network are main mechanisms responsible for the antioxidant action of LC and its derivatives

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This raises questions about cortical involvement and highlights the need for preclinical studies to clarify underlying mechanisms, given the limited accessibility of early-stage, untreated brain tissue from SMA patients

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Mazahery H, Conlon CA, Beck KL, Mugridge O, Kruger MC, Stonehouse W, et al