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All the authors of the present study declare no conflicts of interest

In diabetes, high blood sugar leads to excess production of reactive oxygen species (ROS), which consume glutathione as the body tries to neutralize these harmful molecules, depleting its levels

Consistent with it, increasing evidence suggested that copper-induced oxidative stress contributed to cellular inflammatory responses (Yang et al., 2020

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PPAR- stimulates the synthesis of Bcl-2, which impedes the release of cytochrome c and the activation caspase-3, protecting the cells from apoptosis (Wu 2010

A3 receptor antagonists lower IOP by preventing adenosine-induced activation of Cl- channels in ciliary epithelial cells, while A2A receptor activation in Schlemm's canal cells can have bidirectional effects on IOP (90, 92)