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According to clinical observations reported by Integrative Medicine of Los Angeles, an intramuscular B12 injection is absorbed more slowly over a longer time frame compared to an IV infusion, which delivers the nutrient immediately into the vasculature

Hu S, Zhang X, Unger M, Patties I, Melzer A, Landgraf L

For small (10-to 20-kDa) single-domain proteins, this is usually not problematic, although the overall recoveries may only be 5% to 20% of those of similar or identical proteins expressed in a soluble state