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Physiologically, FA is constantly generated through cellular metabolism, i.e., histone and DNA demethylation reactions or the one-carbon cycle, but it can also arise from the diet and it is ubiquitously found in the environment 2,3,4,5

185 Pyruvate kinase deficiency has a protective effect against replication of the malarial parasite in human erythrocytes.13,58 This protective effect may be related to reduced ATP levels in PK-deficient red blood cells

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