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During the subsequent curing step, the tobacco leaves are dried and bacteria, which proliferate to levels 10 to 20 times higher than on the growing leaf 22 , begin converting the nitrate present in the plant tissue to nitrite, a process called nitrate reduction

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The most common sites for oral cancerous lesions to develop are the lateral border of the tongue (20%), gingiva and cheek (18%), floor of the mouth (12%), lips (11%), and the salivary glands (8%)