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There was plentiful scientific evidence associating smoking with lung cancer and other pulmonary diseases by the 1950s

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Leukocytosis involves an increase in WBCs (above 11,000/L), while leukopenia is a decrease (below 3,500-4,000/L)

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People who smoke more than 15 cigarettes per day have a significantly higher risk of developing this rash during spring or summer.16

In this model, severity reflects the total level of psychopathology across both internalizing and externalizing domains, capturing the extent of comorbidit, since higher severity scores typically indicate the presence of both types of symptoms simultaneously