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During sepsis, immune cells such as neutrophils and macrophages are rapidly activated in response to microbial invasion, releasing large amounts of ROS, including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ), as part of the hosts antimicrobial arsenal (Di Meo et al., 2016)

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Although research on iron metabolism in tumor-infiltrating neutrophils is limited, studies in metastatic breast cancer showed tumor-secreted GM-CSF induces transferrin in neutrophils, stimulating tumor growth via TfR1 [91] (Fig

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During the 2 weeks of trial (014 d PW), ZnO fed piglets had higher average daily gain (165 vs