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This can include mental and emotional stress and trauma which have been identified as common predisposing factors for developing autoimmunity

Tamoxifen activates 50 autophagy and induces apoptosis

MO administration also improved synaptic plasticity and inhibited neurodegeneration in the hippocampus

Different mechanisms, synergistic effects

This is likely to depend on the failure of the autophagy/mitophagy machinery in ATG7 KO, which impedes the membrane elongation process and is inadequate to clear damaged mitochondria

These studies, combined with CKD patient renal biopsies, confirm renal ferroptosis as a key RF driver