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Receptors Based on the Solution Structure of the Peptide Ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH2 Fotsch C, Smith DM, Adams JA, Cheetham J, Croghan M, Doherty EM, Hale C, Jarosinski MA, Kelly MG, Norman MH, Tamayo NA, Xi N and Baumgartner JW Bioorganic & Medicinal Chemistry Letters 13 2003 Case Study-4 : Renin Inhibitors The Renin-Angiotensin System Cascade The First Generation of Renin Inhibitors Example of Inhibitor The Second Generation of Renin Inhibitors 50 = 2 nM) with a relatively low molecular weight (730), however its clinical trials were very disappointing