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(5) the nuclear receptor coactivator of energy expenditure, peroxisome proliferator-activated receptor- coactivator-1 (PGC-1), and its downstream uncoupling protein-1 (UCP-1) ( In addition to the regulation of key metabolic enzymes and transcription factors, emerging evidence suggests that LBPs beneficial effects on glycolipid metabolism are also mediated through epigenetic mechanisms, particularly involving microRNAs (miRNAs), which have been widely documented to exert a specific effect in maintaining glucose homeostasis ( -oxidation of hepatic fatty acids, ultimately reversing IR and abnormal glucose tolerance in HFD-induced GDM mice ( 2.3 LBP restores pancreatic -cell function Insulin, the sole hypoglycemic hormone in the body secreted by pancreatic -cells, is crucially involved in glucose homeostasis (50)

JY: Conceptualization, Project administration, Supervision, Writing original draft, Writing review & editing

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and reducing the abundance of Staphylococcus sp

Unlike in adults, both the HlGST2 gene and protein were upregulated upon larval exposure to a sublethal dose of chlorpyrifos (Additional file 2: Figure S2)

Mo MW, Wang FY, Zhang HM, Zhang Y, Yang CY, Shang JB, et al