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The clinical progression of AD is typically divided into three stages: preclinical, mild cognitive impairment (MCI), and dementia

When unfolded or incorrectly folded proteins are present in the cell, ERS is activated to diminish the concentration of these abnormal proteins and prevent their aggregation

For the specific role and pathogenic mechanisms relating CP, HMGB1 and TF to PD, further exploration and verification are still required

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It is possible to regulate the composition ratio of beneficial bacteria, neutral bacteria, and pathogenic bacteria in gut microbiota by transplanting feces