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Experimental evidence from in vitro studies utilizing human granulosa tumor-derived cell models demonstrates that metformin intervention effectively downregulates multiple components of the LPS-activated inflammatory cascade, including LPS-induced miR-670-3p , NOX2 , NLRP3 , ASC , and GSDMD-N , as well as reducing cellular caspase-1 activity, ROS production, and secretion of inflammatory factors

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Ocular injury models show improvements in corneal repair and reduced scarring after chemical or mechanical damage

10.1073/pnas.87.12.4879 74 GaignardP.SavourouxS.LiereP.PianosA.TherondP.SchumacherM.et al

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G_s-protein-coupled pathways are activated when CJC-1295 (No DAC) binds to pituitary GHRH receptors