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Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): implications in the pathogenesis and treatment of aging-related diseases

Tirzepatide is a dual GIP/GLP-1 receptor agonist that produces mean body weight reductions of 20.9% at 72 weeks by delaying gastric emptying, suppressing ghrelin rebound, and enhancing glucose-dependent insulin secretion

AGEs and ferroptosis AGEs induced oxidative stress and ferroptosis Although hyperglycemia-induced AGEs can trigger oxidative stress, importantly, this pathological state does not directly lead to diabetic complications

doi: 10.1146/annurev.immunol.15.1.323 26 YuHHYangYHChiangBL

Methods Analysis of Human Specimens All human specimens were analyzed after obtaining informed consent with the approval of the Ethics Committee at Kyoto University Hospital (Kyoto, Japan)

Therefore, further clinical trials are necessary to validate their therapeutic efficacy