2-[4-(2-aminoethyl)piperazin-1-yl]ethan-1-amine carboxylic acid 376 SMILES OC(=O)C1CCN(CC1)C1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

376 SMILES OC(=O)C1CCN(CC1)C1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

& Michalski

76 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCC#C)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

324 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(NCCC#C)=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NRX-1933 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

2-[4-(2-aminoethyl)piperazin-1-yl]ethan-1-amine carboxylic acid 376 SMILES OC(=O)C1CCN(CC1)C1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)Nitrogen Heterocycle Based Linker (NHBL). Binfunctional amine amine linker. Product Name 2 [4 (2 aminoethyl)piperazin 1 yl]ethan 1 amine Synonyms Piperazine 1,4 diethylamine CAS Number 6531 38 0 Related CAS Molecular Formula C8H20N4 Molecular Weight 172. 276 SMILES NCCN1CCN(CCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research