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Dysfunctional regulatory factors such as mucins, antimicrobial molecules, cytokines, and immunoglobulins (Igs) are often responsible for impaired barrier integrity that may lead to, or exacerbate, inflammatory diseases including type-1 diabetes (T1D), multiple sclerosis, autoimmune hepatitis, systemic lupus erythematosus (SLE), IBD, and coeliac disease (CD) (Fasano and Shea-Donohue 2005