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GBM is considered an immunologically cold tumor with a very low burden of T-cells in the TME responsible for its poor response to conventional immunotherapy

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The precursor alternative Because cysteine availability limits synthesis, cysteine-donor strategies N-acetylcysteine, L-cystine, or whey protein are often more efficient at raising intracellular glutathione than glutathione itself, which is one reason the Duperray combination trial paired glutathione with L-cystine

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Wever et al., 2018)