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Choi, E

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Importantly, HGF-cMet signaling is crucial for maintaining cellular redox balance, with HGF acting as an antioxidant and c-Met signaling crucial to limiting the overproduction of endogenous ROS (Gloire et al

Currently, most studies concentrate on the impact of APP on the intracellular redox state, including the APP generated reactive species on cellular oxidative stress, leading to lipid peroxidation, DNA damage, mitochondrial dysfunction, and apoptosis 18

Naunyn Schmiedeberg's Arch Pharmacol 379:361369 Cai B, Chang SH, Becker EBE, Bonni A, Xia Z (2006) p38 MAP kinase mediates apoptosis through phosphorylation of Bim EL at Ser-65