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Tumors were excised, photographed, weighed, and processed for immunohistochemistry or Western blot analysis

In addition, a small preliminary study found that creatine supplementation improves muscle strength in ALS patients (Mazzini 2001)

*Correspondence: Yajun Lin, [email protected] Liu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The first AAA to enter in clinical trials for AD was bapineuzumab (Rinne et al., 2010), which was shown to penetrate mouse brain in only 0.07% of injected dose when administer intravenously (Sperling et al., 2012), resulting in clinical trial failure