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Short-term exercise primarily induces acute antioxidant and metabolic responses (Zhang et al., 2024d), while sustained training over weeks to months consolidates ferroptosis resistance through structural remodeling, improved organelle quality control, and durable anti-inflammatory reprogramming

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As set forth above, to overcome the inherent limitations of many individual small molecule collections (Macarron et al., 2011), a custom screening library of 9,517 small molecules derived from a starting pool of 3,372,615 commercially available compounds that were filtered in silico on the basis of drug-likeness, solubility, scaffold diversity and other parameters was assembled

Lebepe TC, Maluleke R, Mgedle N, Oluwafemi OS