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Mitochondrial contribution to therapy resistance Mitochondrial adaptability is crucial for cancer cell survival under therapy-induced stress

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Estey EH, Thall P, Pierce SA, Fayad L, Kornblau SM , Kantarjian HM, Keating MJ

Our 2.43 resolution cryo-EM structure reveals precisely how seven stabilizing mutations cooperatively enhance inter-protomer contacts and rigidify surface loops to lock the particle in its immunogenic state

Loss of RPRM expression is associated with increased proliferation and growth of GC cells, and this poorly understood gene family has the potential for new translational applications as biomarkers for early screening in the future ( 3.1.4 Pancreatic cancer (PC) Pancreatic cancer is a highly aggressive malignancy that is often not detected until it has reached an advanced stage