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In addition, elevated CP enhances the expression of HIF-1, forming a positive feedback loop of HIF1/CP, thereby promoting HCC radioresistance

Moreover, periodontal pathogens like Porphyromonas gingivalis can translocate into systemic circulation, exacerbating endothelial dysfunction and contributing to atherogenesis

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In 2020, the World Health Organization (WHO) ranked cancer as the first or second leading cause of death before the age of 70 in more than half of the countries around the world, and it was also a substantial cause of death in the remaining countries (Sung et al

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Accumulation of -synuclein in microglia was also accompanied by upregulation of proinflammatory chemokines and infiltration of T cells into the SNpc [90]