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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

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To address this issue, we evaluated a potential triple combination therapy, comprising two metabolic-targeting drug and a chemotherapeutic agent, aiming to develop a more effective therapeutic approach for MNA NB

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In addition to IV therapy, eating bland foods such as dry cereal, saltine crackers, oatmeal, and potatoes can help ease symptoms and support recovery