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doi: 10.1176/appi.ajp.2020.20091382 14

reported that the anti-HGF mAb ficlatuzumab significantly inhibited the c-MET activation and rescued the capacity of cetuximab to inhibit the phosphorylation of EGFR in cetuximab-resistant CRC cell lines LM1215, SW48, and DiFi ( Rilotumumab , a fully human anti-HGF mAb that neutralizes HGF-dependent c-MET signaling, has been investigated in phase Ib/II trial (NCT00788957) in combination with panitumumab in previously treated patients with KRAS-WT mCRC

In ovarian cancer, SIRT1 inhibits the transcriptional activity of HIF-1 through deacetylation, thereby preventing the mesenchymal transformation of ovarian cancer cells 42

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Donovan J (2015) Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP)

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