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Contraindicated in people with a history of severe allergic reactions

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One potential mechanism is that H 2 S 2 and H 2 S 3 produced by 3MST readily react with free cysteine and GSH to produce Cys-SSH and GSSH, and react with cysteine residues of proteins to generate persulfurated proteins (Figs 2 and 8a)

The QuantiTect probe RT-PCR kit (Cat#204443, QIAGEN Sciences Inc.) was employed to carry out quantitative real-time PCR (qRT-PCR)

Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)