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Even modest volumes of free water could potentially affect their fluid and electrolyte balance

In other experiments, ADMSCs were loaded into acellular NP scaffolds that simulated natural NP components, and the scaffolds were implanted into a rabbit IDD model

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It also participates in the methylation cycle, a process connected to functions like DNA synthesis, immune health, and hormone regulation

Animal studies show no toxicity at therapeutic doses, but human data is insufficient for regulatory approval

However, also dietary/drinking water Se excess is associated with infertility and testicular degeneration in experimental animals, related to higher GPX4 and lactate dehydrogenase activity and higher hydrogen selenide production, and reduced spermatozoa motility, concentration, and typical spermatozoa morphological defects (with the fusion of two midpieces, vacuolization of the cytoplasm, and twisted tails) (85, 105, 117, 169)