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Those who underwent a gastric bypass may have compromised their stomachs ability to release B12 from food

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Some common symptoms of deficiency include: Chronic fatigue and weakness Brain fog and difficulty focusing Mood disturbances, including irritability and depression Numbness or tingling in the hands and feet Pale or jaundiced skin B12 plays a crucial role in red blood cell formation and nerve function, so inadequate levels can lead to long-term health complications if left unaddressed

Additional supplementation with key nutrients recommended alongside tirzepatide can help prevent common deficiencies and support better outcomes

The CagriSema trials used 2.4 mg as the target, and the Phase 3 monotherapy data also used 2.4 mg