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[513] extensively review the involvement of BBB breakdown and dysfunction in neurological deficits and other pathologies, including chronic conditions (Alzheimer's disease, Parkinsons disease, amyotrophic lateral sclerosis, and multiple sclerosis), as well as acute CNS disorders such as stroke, traumatic brain injury, spinal cord injury, and epilepsy

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Summary and Conclusions Some of the inter-relationships between IDO or its kynurenine-derived catabolites and aspects of the immune system have been discussed, focusing on several examples of disorders affecting peripheral tissues or the CNS