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doi: 10.3389/fendo.2026.1822475 Received 03 March 2026 Revised 05 May 2026 Accepted 02 June 2026 Published 18 June 2026 Volume 17 - 2026 Edited by Carmine Bruno, Link Campus University, Italy Reviewed by Matej Rakusa, University Medical Centre Ljubljana, Slovenia Fredrik Tiberg, Camurus AB, Sweden Updates Copyright 2026 Dominikowski, Rko, Olejarz, Szczepanek-Parulska, Domin and Ruchaa

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Immunometabolic rewiring of tubular epithelial cells in kidney disease

5-amino-1MQ did not inhibit SIRT1 concentrations ranging from 10 nM 300 M, and minor reduction in SIRT1 activity was observed with 600 M 5-amino-1MQ (Figure 4E)

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They are not magic bullets, so they work best layered onto a foundation of good training, protein, and sleep