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We have previously established an experimental system based on human primary fibroblasts undergoing mild and progressive ER stress upon starvation for glucose and serum (GS starvation) (Michael et al, 2023), and showed that up-regulated ATF4 and IRE1a drive the UPR and a cytokine and chemokine response (Michael et al, 2023)

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Additionally, treatment with TJ515 alone for 40 weeks also increased the strain relative to that recorded in control vehicle-treated rats (Fig