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Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

In isolated human islets, somatostatin is released in response to increasing glucose concentrations ( Endogenous somatostatin is regulated by intra-islet paracrine influences ( The emerging picture of healthy glucose-insulin secretion coupling is less an isolated -cell driven action, but more a finely tuned paracrine counterbalance between all islet cell components

Manifestations of gMG therefore commonly include muscle weakness, which patients often initially notice in their eye movements or jaw

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Representative data of 34 experiments (n = 5, two-sided unpaired t-test)

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