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Iron metabolism and ferroptosis may induce neurological damage through interactions with the central nervous system, gut microbiota, and brain-gut axis, positioning them as potential therapeutic targets for depression (Figure 3)

Glutaminase inhibitors induce thiol-mediated oxidative stress and radiosensitization in treatment-resistant cervical cancers

Bailey AP, Koster G, Guillermier C, Hirst EMA, MacRae JI, Lechene CP, et al

Nonetheless, the physiological roles of these enzymes can certainly be better understood by delineating the gene expression in plant organs or in response to environmental constraints

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Disrupting their mechanical or biochemical interactions with tumor cells holds potential for sensitizing ovarian cancers to platinum therapy and breaking immune suppression