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Muscular dystrophy, diarrhea, chronic arrhythmia hypertension, thyroid dysfunction

Adipose-specific Rictor knockout mice exhibit increased lean mass, likely due to elevated hepatic IGF-1 and pancreatic insulin secretion, as mTORC2 in white adipose tissue negatively regulates these hormones via feedback loops

Moreover, mice with systemic knockout of SLC25A39 (including the heart) exhibited severe anemia, a complete lack of red blood cells, and iron overload [62]

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For example, the peak reduction of the NADP pool coincided with the highest H 2 O 2 levels

Preclinical studies (in vitro and animal) reveal mechanistic benefits such as gut microbiota modulation, improved barrier function, and metabolic regulation