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Despite that low penetrance, partial deficiency of CCT in B cells resulted in decreased peritoneal and splenic B cell numbers, inducing a compromised proliferation, especially in the periphery, decreasing serum IgG concentration, and increasing the incidence of IgM-secreting cells (107)

H.DohnerH.PocockC.MontesinosP.AfanasyevB.DombretH.et al (2020)

One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint

Guequn A, Zamorano P, Crdova F, Koning T, Torres A, Ehrenfeld P, Boric MP, Salazar-Onfray F, Gavard J, Durn WN, et al

Moreover, indirect perturbations have shown the ability to restore AR expression as well

Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders