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Dzce niversitesi Bilim ve Teknoloji Dergisi 9 (3), 226261

Nuclear Depletion and Cytoplasmic Accumulation of TDP-43 One of the prominent features of ALS and FTLD-TDP, is the loss of functional TDP-43 in the nucleus and its increased deposition into cytoplasmic inclusion bodies in the brain and spinal cord neurons (Arai et al., 2006

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Chronic inflammation contributes to neurotransmitter imbalance by reducing levels of 5-HT, DA, and GABA while enhancing GLU excitotoxicity, thereby accelerating the progression of EDC