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BELN supplementation also improves liver dysfunction and insulin resistance in NAFLD, which is accompanied by a reduction in AST and ALT levels and fat deposition as well as a downregulation in acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) expression (252)

Once cirrhosis is developed, it predisposes to portal hypertension and organ failure complications and progresses into HCC (Fig

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