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Mitochondria are a major source of intracellular reactive oxygen species (ROS), whose accumulation is buffered by GSH-dependent enzymes (Handy et al, 2009

The advantages of nanoparticle-based therapeutic systems primarily lie in their ability to enhance drug stability, prolong circulation time, and enable site-specific delivery

Electrophysiological and c-Fos mapping studies in rodent models have demonstrated that amylin receptor activation in these regions inhibits gastric emptying, reduces meal size, and activates downstream satiety circuits projecting to the hypothalamic arcuate nucleus (Lutz et al., Physiology & Behavior, 2010)

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VHL The Von Hippel-Lindau (VHL) protein is a pivotal tumor suppressor involved in the regulation of gene expression, maintenance of cellular oxygen homeostasis, and the ubiquitination and subsequent proteasomal degradation of hypoxia-inducible factors (HIFs)

The level of oxidative stress, quantified by the oxidative stress markers, has been found elevated in aging individuals or people with bad lifestyles, taking unhealthy food, smoking, drinking alcohol, lack of physical exercise, and genetic predisposition