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Neuronal redox-imbalance in Rett syndrome affects mitochondria as well as cytosol, and is accompanied by intensified mitochondrial O 2 consumption and ROS release

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Inspired by aforementioned reasons and as a part of the ongoing work in our research groups aimed at the search of novel antidepressants 6,34 with neuroprotective mechanism, we started a scaffold hopping campaign of Agomelatine in silico

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Limited safety data on combinations in existing literature further emphasizes the need for cautious protocol design

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During ischemia-reperfusion injury, NOX overexpression and enhanced activity contribute to ROS generation, subsequently promoting cellular ferroptosis

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Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform

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[35] van der Flier LG, Clevers H

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