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Considering that the cellular levels of CrP can be increased in astrocytes by application of creatine [55], it should be studied whether creatine supplementation may also increase the level of CrP in astrocytes in the brain and whether such a process may contribute to the reported beneficial consequences of a creatine supplementation for the brain [133, 255, 256]

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This study was approved by the Radiation Drug Safety Committee and the Institutional Review Board of the former National Institutes for former Quantum and Radiological Science and Technology, Japan, and by the institutional review board of Showa University Karasuyama Hospital, Japan

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