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demonstrated that genetic ablation of GPX4 in mice leads to acute renal failure and renal tubular ferroptosis, highlighting the enzymes critical role in preventing ferroptosis (Table 2)

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Two other monoclonal antibodies failed to demonstrate efficacy in phase II trials, sirukumab (104), and vobarilizumab

Polacco JC, Mazzafera P, Tezotto T (2013) OpinionNi and urease in plants: still many knowledge gaps

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Proc Natl Acad Sci USA 102(47):1721317218