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The results suggested that TB-500 not only potentially enhanced the viability, angiogenesis, and migratory ability of HUVEC but possibly also promoted the expression of angiopoietin-2 (Ang2), TEK receptor tyrosine kinase 2 (tie2), vascular endothelial growth factor A (VEGFA), NOTCH1 intracellular domain (N1ICD), Notch receptor 3 (Notch3), NF-B, and phosphorylated (p)-p65 in HUVEC

Do not re-treat animals for 8 weeks after the last treatment

In addition, Fosamax is approved to treat Pagets disease of the bone

In fact, there was a published case of a lactating woman who had food borne botulism (exponentially higher amount of toxin load than what is received during a Botox treatment)

*Correspondence: Mingyu Sun, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

(Basel) 14 , 4674 (2021)