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The increased PolyQ length results in aggregation of protein Huntingtin leading to neuronal cell death

Huybrechts M, Cuypers A, Deckers J, Iven V, Vandionant S, Jozefczak M, Hendrix S

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

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Its scientific relevance lies primarily in: precise GH stimulation through GHS-R agonism with minimal influence on cortisol and prolactin levels, its mechanistic value for studying the growth hormone axis and metabolic regulation , preclinical effects on IGF-1 signaling, bone homeostasis, and gastrointestinal function , which provide useful models for further research

Wang, Y., Argiles-Castillo, D., Kane, E.I., Zhou, A