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and may guide intensification of treatment of COVID-19-associated uncontrolled inflammation (99, 183, 261, 262, 265, 267269)

Beneficial properties of VA include bioactivity against diabetes and obesity 12

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ALOX5 oxidizes arachidonic acid to generate leukotriene A4, which is rapidly converted to LTB4 by the enzyme LTA4 hydrolase or conjugated to glutathione to generate LTC4, the parent of all cysteinyl leukotrienes, by LTC4 synthase (LTC4S) (Fig

What sets this review apart is its focus on the translational dimension: highlighting recent advances in delivery systems to overcome bioavailability challenges and identifying gaps that must be addressed through clinical research