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Both, the alpha-class related gst-32 and the GPX are implicated in the oxidative stress response by way of their GSH-dependent reduction of inorganic and organic peroxides or by their ability to eliminate secondary products of lipid peroxidation

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In aged rodents, spermidine (SPD) or spermine (SPM) increased median and maximal lifespan by 1018% and reduced mortality by up to 35%, while maintaining cardiac, metabolic, hepatic, and neuronal functions [103,104]