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2019;37(7):TPS682

Several studies have shown that Yang/Qi-invigorating tonic botanical drugs can enhance mitochondrial ATP generating capacity (ATP-GC) by increasing mitochondrial electron transport in various types of cells and tissues in situ and ex vivo , which thus delineates the biochemical basis of Yang/Qi-invigoration in TCM ( Cistanche deserticola Y

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Regulatory factors like heme oxygenase 1 (HO-1) and Poly(rC) binding proteins (PCBPs) also influence iron homeostasis, with HO-1 overexpression reducing ROS and lipid peroxidation to inhibit ferroptosis, as shown by Villalpando-Rodriguez et al

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However, another report demonstrated mitochondrial stress and bioenergetics defects in GPx1 null mice ( Figure 3 ), and hence plays a key role in protecting phospholipids, cholesteryl esters and cardiolipin and defense against apoptosis and maintenance of ETC and OXPHOS ( + / - cells are sensitive to oxidative stress triggers (Legault et al., 2000