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reported that selenium sulfide (SeS 2 ) could inhibit the C-MET/STAT3, AKT/mTOR, and MAPK signaling pathways, and trigger Bcl-2/Cyto C/Caspase-mediated intrinsic mitochondrial apoptosis both in vitro and in vivo ( 96) ( Figure 2 )

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In the course of this astrogliosis in glaucoma, there is also increased expression of the phagocytosis-related Mac-2 gene and ET-1 by astrocytes, demonstrating both their role in phagocytosis of damaged or dead RGC debris and their involvement in glaucoma-associated vascular dysregulation (Nickells et al., 2012

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